Document Detail


A case of severe cerebral trauma in a patient under chronic treatment with cyclosporine A.
MedLine Citation:
PMID:  9559768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of severe cerebral head injury in a child, chronically treated with cyclosporine A after orthotopic liver transplantation, is presented. The initial Glasgow Coma Scale score after the motor vehicle accident was 3, and computed tomography showed multiple sites of intracerebral bleeding, an epidural hematoma, and signs of perifocal edema. Although these lesions are normally associated with a poor outcome, the child recovered unexpectedly well. In brain injury, a lucid interval can be followed by secondary neurologic deterioration due to a loss of high-energy metabolites, a release of neurotransmitters, and an increase in intracellular Ca2+. These events finally led to cell damage in the penumbra of an ischemic infarction. Among other drugs, immunosuppressants such as cyclosporine A have been shown to exhibit neuroprotective properties in experimental models if given during this time interval of secondary neurologic deterioration. Although human data on these effects are still lacking, we conclude that neuroprotective actions of cyclosporine A may have been involved in the favorable outcome in this 14-year-old boy.
Authors:
W Gogarten; H Van Aken; D Moskopp; N Roos; J Schleef; M Marcus; J Meyer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  10     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-17     Completed Date:  1998-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Affiliation:
Klinik und Poliklinik für Anësthesiologie und operative Intensivmedizin, Westfëlische Wilhems-Universitët, Münster, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain Injuries / pathology,  physiopathology*,  radiography
Cyclosporine / adverse effects*,  therapeutic use
Glasgow Coma Scale
Graft Rejection / prevention & control
Humans
Immunosuppressive Agents / adverse effects*,  therapeutic use
Liver Transplantation / immunology
Magnetic Resonance Imaging
Male
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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