Document Detail

A case series of nephrogenic adenoma of the urethra and bladder in children: Review of this rare diagnosis, its natural history and management, with reference to the literature.
MedLine Citation:
PMID:  18947630     Owner:  NLM     Status:  In-Data-Review    
Nephrogenic adenoma (NA) is a rare benign tumour of the urinary tract and is found most commonly in the bladder. Here are presented four cases of paediatric NA, two bladder and two urethral. Their diagnostic and management features in the context of differential diagnosis and natural history are discussed. A 3-year-old girl presented with recurrent urinary tract infections (UTIs) and haematuria. She had undergone a previous hemi-nephro-ureterectomy. An ultrasound scan suggested a large bladder tumour, which was biopsied cystoscopically, and histology confirmed an NA. She then underwent open resection of the tumour. A 4-year-old girl presented with recurrent UTIs and a history of previous bilateral duplex ureterostomies and subsequent trans-uretero-ureterostomy with ureteric re-implantation. A cystoscopy showed a papillary tumour, which was confirmed as NA on histology. An 11-year-old boy presented with haematuria and dysuria and no other relevant history. At urethroscopy a ragged area biopsied in the bulbar urethra showed NA. A 7-year-old boy presented with haematuria and no other relevant history. At urethroscopy an inflamed nodular area was biopsied and nephrogenic adenoma confirmed. In the two bladder cases, but not the urethral cases, a causative factor could be identified. Recurrence was noted in both of the bladder cases. The urethral cases had persistent symptoms suggestive of continuing NA. Treatment consisted of endoscopic and open ablation of the tumours, and endoscopic fulguration of recurrences for the bladder cases, and surveillance for the urethral cases. Only two previous cases of urethral and 25 cases of bladder NA have been reported in children.
T J Crook; Z Mead; B Vadgama; P S J Malone
Publication Detail:
Type:  Journal Article     Date:  2006-04-17
Journal Detail:
Title:  Journal of pediatric urology     Volume:  2     ISSN:  1873-4898     ISO Abbreviation:  -     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2008-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233150     Medline TA:  J Pediatr Urol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  -    
Department of Paediatric Urology, Southampton University Hospital, Tremona Road, Southampton, Hants SO16 6YD, UK.
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