Document Detail


A case of sarcoidosis presenting as a non-specific intramedullary lesion.
MedLine Citation:
PMID:  17355560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurosarcoidosis occurs in 5-15% of sarcoidosis cases. Approximately 50% of patients with neurosarcoidosis present with a neurological disease at the time sarcoidosis is first diagnosed. Spinal sarcoidosis is rare. We report the case of a 61-year-old man with a highly aspecific intramedullary lesion as the first manifestation of sarcoidosis. One year after the onset of neurological symptoms, the high levels of angiotensin-converting enzyme and the results of a total body gallium scan and bronchoalveolar lavage supported the diagnosis of sarcoidosis. Isolated single reports indicate that spinal neurosarcoidosis may be the initial manifestation of sarcoidosis. In our case, magnetic resonance imaging of the dorsal spine showed a largely aspecific lesion. Neurosarcoidosis should be considered in the differential diagnosis of intramedullary cord lesion with leptomeningeal enhancement; a systematic search for evidence of sarcoidosis should be mandatory in all cases for a correct diagnosis and early treatment.
Authors:
D Caneparo; C Lucetti; A Nuti; G Cipriani; C Tessa; P Fazzi; U Bonuccelli
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  IM    
Affiliation:
Section of Neurology, Department of Neuroscience, University of Pisa, Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Bronchoalveolar Lavage
Diagnosis, Differential
Disease Progression
Gallium / diagnostic use
Humans
Lung / pathology,  physiopathology
Magnetic Resonance Imaging
Male
Meninges / pathology,  physiopathology
Middle Aged
Peptidyl-Dipeptidase A / blood
Predictive Value of Tests
Sarcoidosis / complications*,  pathology*,  physiopathology
Selenium / diagnostic use
Spinal Cord / pathology*,  physiopathology
Spinal Cord Diseases / etiology*,  pathology*,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/gallium selenide; 7440-55-3/Gallium; 7782-49-2/Selenium; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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