Document Detail

A case of rofecoxib-associated stevens-johnson syndrome with corneal and conjunctival changes.
MedLine Citation:
PMID:  15448505     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a case of rofecoxib (Vioxx)-associated Stevens-Johnson syndrome with corneal and conjunctival changes. DESIGN: Interventional case report. METHODS: Case report of a 62-year-old woman with systemic lupus erythematosus (SLE) taking rofecoxib for arthritis for 3 weeks. RESULTS: Stevens-Johnson syndrome after 3 weeks of rofecoxib therapy. CONCLUSION: This case report suggests that oral rofecoxib may trigger Stevens-Johnson syndrome, potentially causing symblepharons, corneal neovascularization and cicatricial ectropions.
D Goldberg; D Panigrahi; M Barazi; M Abelson; S Butrus
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cornea     Volume:  23     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-12-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  736-7     Citation Subset:  IM    
Department of Ophthalmology, The Georgetown University-Washington Hospital Center, Washington, DC, USA.
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MeSH Terms
Arthralgia / drug therapy
Conjunctiva / pathology*
Cornea / pathology*
Cyclooxygenase Inhibitors / adverse effects*
Lactones / adverse effects*
Middle Aged
Stevens-Johnson Syndrome / chemically induced*,  pathology*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Lactones; 0/Sulfones; 0/rofecoxib

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