Document Detail

A case of resolution of an acute psychotic episode after high fever.
MedLine Citation:
PMID:  17545955     Owner:  NLM     Status:  MEDLINE    
Fever (pyretotherapy) was used for psychosis during the turn of the 19th century, but pyretotherapy (ie, the treatment of a disorder by inducing fever) fell out of use after the introduction of convulsive methods. Here, we report on a case of schizoaffective disorder and review classical and recent literature on fever and psychosis. The patient developed auditory hallucinations, persecutory delusional ideas, and was terrified soon upon his arrival in a foreign country. After being treated for 12 days with olanzapine and haloperidol, he developed a fever due to urinary infection; his creatine phosphokinase levels were high, prompting the suspension of antipsychotics. Psychotic symptom resolution followed immediately fever abatement. Antipsychotics were reintroduced at lower dosages. He was discharged asymptomatic with a prescription of olanzapine 15 mg/day and haloperidol 3 mg/day. The time course of symptom resolution in this patient suggests that fever had a beneficial role in this case. The associations between body temperature changes and psychotic symptoms need to be further studied.
Gabriele Sani; Giovanni Manfredi; Isabella Pacchiarotti; Saverio Simone Caltagirone; Iginia Mancinelli; Alexia E Koukopoulos; Caterina Tatarelli; Giorgio D Kotzalidis; Roberto Tatarelli; Paolo Girardi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  CNS spectrums     Volume:  12     ISSN:  1092-8529     ISO Abbreviation:  CNS Spectr     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702877     Medline TA:  CNS Spectr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  IM    
Medical School II, Department of Psychiatry, Sapienza University, Sant'Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.
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MeSH Terms
Fever / psychology*
Hyperthermia, Induced
Psychotic Disorders / psychology*
Staphylococcal Infections / psychology

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