Document Detail

A case report of severe visceral beta2-microglobulin-derived amyloidosis without obvious joint symptoms or radiological findings in a chronic hemodialyzed patient with systemic lupus erythematosus.
MedLine Citation:
PMID:  19527472     Owner:  NLM     Status:  MEDLINE    
Beta-2-microglobulin-derived amyloidosis (Abeta2M amyloidosis) is a critical complication for patients undergoing long-term renal replacement therapy. Osteoarticular lesions, rather than visceral organs, are susceptible to this type of amyloidosis, and the visceral form seems to occur at a relatively late stage. Herein, we report a case of severe visceral Abeta2M amyloidosis without obvious joint symptoms or radiological findings in a chronic hemodialyzed patient who had received long-term treatment with glucocorticoid steroids for systemic lupus erythematosus. It should be noted that prominent visceral Abeta2M amyloidosis can develop without any osteoarticular symptoms or radiological abnormalities in dialyzed patients undergoing prolonged glucocorticoid therapy.
Ryo Koda; Hajime Yamazaki; Junichiro Kazama; Tomoyuki Ito; Takako Saeki; Iwao Emura; Syoji Miyamura; Ichiei Narita; Fumitake Gejyo
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  13     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Nagaoka Red Cross Hospital, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Japan.
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MeSH Terms
Amyloidosis / etiology*,  physiopathology
Glucocorticoids / adverse effects,  therapeutic use
Lupus Erythematosus, Systemic / complications,  drug therapy
Lupus Nephritis / therapy
Middle Aged
Renal Dialysis / adverse effects*
Severity of Illness Index
Time Factors
beta 2-Microglobulin / metabolism*
Reg. No./Substance:
0/Glucocorticoids; 0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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