Document Detail

A case report of a premature infant with coxsackie B1 meningitis.
MedLine Citation:
PMID:  18049150     Owner:  NLM     Status:  MEDLINE    
This case report describes a 36-week gestational age infant diagnosed with coxsackie B1 meningitis at 20 days of age. A head ultrasound 5 days after diagnosis was consistent with cystic periventricular leukomalacia. The scientific literature does not clearly elucidate differences between bacterial and viral infections in infants. When difficulties arise, it is pertinent to consider a viral etiology for the underlying illness and obtain a detailed maternal and infant history focusing on clinical symptoms, seasonality, geographic location, exposure, and incubation period. Polymerase chain reaction is a rapid and sensitive diagnostic test for the identification of enteroviruses in cerebrospinal fluid, blood, urine, and throat specimens and should be performed as part of the general workup in the evaluation of a febrile infant with sepsis. In retrospect, it may have established an earlier diagnosis of meningitis, consequently preventing the unnecessary use of antibiotics, potentially decreasing the length of hospitalization, and eliminating the need for more detailed investigations to rule out other etiological factors. In addition, treatment with pleconaril may have affected the severity of the encephalitis. This article reviews the pathogenesis, clinical manifestations, and differential diagnoses of enteroviral infections, specifically focusing on the prevention, treatment, and prognosis of the disease and the implications for clinical practice.
Jennifer Callen; Bosco A Paes
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Advances in neonatal care : official journal of the National Association of Neonatal Nurses     Volume:  7     ISSN:  1536-0903     ISO Abbreviation:  Adv Neonatal Care     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125644     Medline TA:  Adv Neonatal Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-47     Citation Subset:  IM    
McMaster Children's Hospital, Hamilton, Ontario, Canada.
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MeSH Terms
Child, Preschool
Coxsackievirus Infections / diagnosis*,  physiopathology,  transmission
Developmental Disabilities / virology*
Enterovirus B, Human / pathogenicity
Infant, Newborn
Infant, Premature*
Leukomalacia, Periventricular / physiopathology,  virology*
Meningitis, Viral / diagnosis*,  physiopathology
Pregnancy Complications, Infectious / surgery

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