Document Detail

A case report of multicentric verrucous carcinoma of the female genital tract.
MedLine Citation:
PMID:  12893224     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Verrucous carcinoma is a variant of squamous cell carcinoma with distinct features including slow locally invasive growth and verrucous appearance. Verrucous carcinoma of the vagina is considered an extremely rare lesion because only 17 cases have been reported in the literature. CASE: We report a case of vaginal verrucous carcinoma with a second focus in the cervix. The patient was treated with surgery and adjuvant interferon therapy for local recurrence. Human papillomavirus was detected in both vaginal and cervical tumor tissue by immunohistochemistry. CONCLUSION: Diagnosis of verrucous carcinoma may be difficult, particularly if biopsy specimen involves only the surface epithelium. The role of human papillomavirus as an etiologic agent in verrucous carcinoma is still a matter of discussion. Effective management requires surgical resection. The efficiencies of radiotherapy and interferon therapy are discussed.
Aycag Yorganci; Ebru Serinsoz; Arzu Ensari; Ayse Sertcelik; Firat Ortac
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  90     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  478-81     Citation Subset:  IM    
Ankara Numune Research and Training Hospital, Clinic of Obstetrics, Ankara, Turkey.
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MeSH Terms
Carcinoma, Verrucous / pathology*
Neoplasms, Multiple Primary / pathology*
Vaginal Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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