| A case report of heparin resistance due to acquired antithrombin III deficiency. | |
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MedLine Citation:
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PMID: 10101569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of heparin resistance and its management during cardiopulmonary bypass is reported. A patient with a history of post-infarct angina and arrhythmias was treated with intravenous heparin infusion for five days prior to myocardial revascularisation surgery. He required 13,500 IU/kg of heparin to increase his activated clotting time to a therapeutic level for safe institution of cardiopulmonary bypass. This phenomenon of heparin resistance was postulated to be due to consumption of circulating antithrombin III as a result of prior heparinisation. Treatment with fresh frozen plasma restored heparin effectiveness. |
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Authors:
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C K Leong; B C Ong |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of the Academy of Medicine, Singapore Volume: 27 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 877-9 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / administration & dosage, adverse effects* Antithrombin III Deficiency / chemically induced* Blood Coagulation / drug effects* Cardiopulmonary Bypass* Drug Resistance Heparin / administration & dosage, adverse effects* Humans Infusions, Intravenous Male Whole Blood Coagulation Time |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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