Document Detail

A case report of heparin resistance due to acquired antithrombin III deficiency.
MedLine Citation:
PMID:  10101569     Owner:  NLM     Status:  MEDLINE    
A case of heparin resistance and its management during cardiopulmonary bypass is reported. A patient with a history of post-infarct angina and arrhythmias was treated with intravenous heparin infusion for five days prior to myocardial revascularisation surgery. He required 13,500 IU/kg of heparin to increase his activated clotting time to a therapeutic level for safe institution of cardiopulmonary bypass. This phenomenon of heparin resistance was postulated to be due to consumption of circulating antithrombin III as a result of prior heparinisation. Treatment with fresh frozen plasma restored heparin effectiveness.
C K Leong; B C Ong
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  27     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  877-9     Citation Subset:  IM    
Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore.
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MeSH Terms
Anticoagulants / administration & dosage,  adverse effects*
Antithrombin III Deficiency / chemically induced*
Blood Coagulation / drug effects*
Cardiopulmonary Bypass*
Drug Resistance
Heparin / administration & dosage,  adverse effects*
Infusions, Intravenous
Whole Blood Coagulation Time
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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