Document Detail

A case report of the effect of acetate-free biofiltration on arrhythmia in a hemodialysis patient.
MedLine Citation:
PMID:  17381538     Owner:  NLM     Status:  MEDLINE    
This case report concerns a hemodialysis patient with arrhythmia. A 71-year-old man had undergone hemodiafiltration (HDF) for 17 years for the treatment of chronic glomerulonephritis. Because of repeated heart failure and chronic atrial fibrillation, he could not continue receiving standard hemodialysis, which is hemodialysis using bicarbonate dialysate including a small amount of acetate. Neither elevating the sodium concentration of the dialysate nor changing the HDF modality was effective. Acetate-free biofiltration (AFB) was initiated and this treatment dramatically ameliorated the patient's intradialytic acute hypotension and arrhythmia. The patient's quality of life subsequently improved and his scores on the Short-form 36 questionnaire (a measure of quality of life) increased. AFB is an HDF technique based on the continuous postdilution infusion of a sterile isotonic bicarbonate solution. Previous studies have reported that acetate induces chemical cytokines and vasodilator substances. AFB may be effective for preventing acute hypotension and arrhythmia during dialysis and may improve quality of life, including mental status.
Shunji Shiohira; Kan Kikuchi; Takumi Yoshida; Misao Tsukada; Kosaku Nitta; Takashi Akiba
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  11     ISSN:  1744-9979     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-11-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.
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MeSH Terms
Arrhythmias, Cardiac / therapy*
Chronic Disease
Glomerulonephritis / therapy
Hemodiafiltration / methods*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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