| A case report of the cascade filtration system: a safe and effective method for low-density lipoprotein apheresis during pregnancy. | |
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MedLine Citation:
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PMID: 18937724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Women with familial hypercholesterolemia (FH) should be treated effectively during pregnancy, as elevated low-density lipoprotein cholesterol (LDL-C) levels may result in life-threatening consequences. Hydroxymethylglutaryl-coenzyme A reductase inhibitors are contraindicated during pregnancy, therefore LDL apheresis should be considered in the management of such pregnant cases. There are five different methods of selective LDL apheresis: heparin-induced extracorporeal LDL precipitation, double filtration plasmapheresis, direct adsorption of lipoproteins, dextran sulfate adsorption, and LDL immunoadsorption. The cascade filtration system is another modern and effective method for the extracorporeal elimination of LDL-C, although it is not as selective as the methods mentioned above. Herein, we present the case of a pregnant woman with heterozygous FH and extremely elevated LDL-C levels who has been successfully treated with the cascade filtration system until delivery. As far as we can ascertain, LDL apheresis with the cascade filtration system during pregnancy has not yet been reported in the literature. |
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Authors:
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Melek Eda Ertorer; Birol Guvenc; Bulent Haydardedeoglu; Ferda Tekinturhan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 12 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 396-400 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Faculty of Medicine, Baskent University, Ankara, Turkey. e_ertorer@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Component Removal / methods* Cesarean Section Cholesterol, LDL / blood* Combined Modality Therapy Female Follow-Up Studies Gestational Age Hemofiltration / methods Humans Hyperlipoproteinemia Type II / genetics, therapy* Monitoring, Physiologic / methods* Pregnancy Pregnancy Complications / diagnosis, therapy* Pregnancy Outcome* Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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