| A case report of adalimumab-associated optic neuritis. | |
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MedLine Citation:
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PMID: 22271346 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To describe a case of retrobulbar optic neuritis that presented within 3 weeks of adalimumab treatment initiation. METHODS: This index case was evaluated with visual field testing, brain magnetic resonance imaging, lumbar puncture, and laboratory evaluation, and treated with intravenous methylprednisolone followed by a steroid taper. RESULTS: Our patient made a full visual recovery, but was found to have extensive T2/FLAIR foci of hyperintensities that enhanced and had restricted diffusion on magnetic resonance imaging (MRI). Six months later, these demyelinating lesions still persisted and our patient was initiated on immunomodulatory treatment. CONCLUSION: With the extensive burden of disease at presentation and persistence of lesions on follow-up MRI, this unusual case seems to suggest an unmasking of an underlying demyelinating process by adalimumab. The clinician should be mindful of this association and monitor for any manifestations and treat appropriately. |
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Authors:
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Alice Kim; Norman Saffra |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Journal of ophthalmic inflammation and infection Volume: - ISSN: 1869-5760 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101553216 Medline TA: J Ophthalmic Inflamm Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Ophthalmology, Maimonides Medical Center, 902 49th Street, Brooklyn, NY, 11219, USA, aliceskim.md@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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