Document Detail

A case report of the Modified Malmö Protocol: an alternative therapeutic approach to refractory chronic idiopathic thrombocytopenic purpura.
MedLine Citation:
PMID:  18503705     Owner:  NLM     Status:  MEDLINE    
Therapy in refractory chronic idiopathic thrombocytopenic purpura is usually a difficult and expensive procedure, with little benefit to the patient, and the results are typically only short-term improvements. In this case report, we study a patient with refractory chronic idiopathic thrombocytopenic purpura who was initially treated with a first line therapy with only partial and temporary benefit, and in whom none of the experimental therapies tried later on resulted in any long lasting effect. In the case study conducted, among all the second-line experimental treatment modalities, only the proposed new protocol (the Modified Malmö Protocol) resulted in a major response. Our results suggest that, the Modified Malmö Protocol may be a promising second-line treatment option for severely refractory idiopathic thrombocytopenic purpura cases.
Dilek Yazman; Nahide Konuk; Muhit Ozcan; Mutlu Arat; Ender Soydan; Onder Arslan; Osman Ilhan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  12     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Hematology Department, Dr Burhan Nalbantoglu State Hospital, Lefkosa, Turkey.
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MeSH Terms
Cyclophosphamide / administration & dosage*
Drug Combinations
Factor IX / administration & dosage*
Factor VII / administration & dosage*
Factor VIII / administration & dosage*
Immunoglobulin G / administration & dosage*
Purpura, Thrombocytopenic, Idiopathic / therapy*
Reg. No./Substance:
0/Drug Combinations; 0/Immunoglobulin G; 0/malmo protocol; 50-18-0/Cyclophosphamide; 9001-25-6/Factor VII; 9001-27-8/Factor VIII; 9001-28-9/Factor IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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