| A case of renal involvement in persistent immune activation caused by chlamydial salpingitis. | |
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MedLine Citation:
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PMID: 11315629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 24-year-old woman presented with renal insufficiency, macrohematuria, and mild urinary protein. Polyclonal hypergamma-globulinemia, thrombocytosis, increased concentration of serum, and urinary interleukin (IL)-6 all indicated persistent immune activation caused by a Chlamydia trachomatis infection of the fallopian tube. Gynecological treatment with levofloxacin was effective both for the renal symptoms and other immunological parameters. First and second renal biopsy specimens showed an immune-complex glomerulopathy with extensive interstitial infiltration of many types of inflammatory cells, including plasma cells. Thus, we conclude that chlamydial salpingitis must be considered as one causative disease factor for renal involvement by means of its persistent immune activation effects. |
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Authors:
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I Ohsawa; H Ohi; M Endo; T Fujita; M Hidaka; A Satomura; Y Yamaguchi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 438 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-23 Completed Date: 2001-05-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, Nihon University School of Medicine, Oyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan. iohsawa@med.nihon-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen-Antibody Complex / metabolism* Chlamydia Infections / complications, pathology* Chlamydia trachomatis* Female Glomerulonephritis, IGA / etiology Humans Interleukin-6 / physiology Kidney / pathology* Salpingitis / complications, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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