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A case of refractory adult-onset Still's disease successfully controlled with tocilizumab and a review of the literature.
MedLine Citation:
PMID:  20734215     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Adult-onset Still's disease (AOSD) is an uncommon systemic inflammatory disease of unknown aetiology. Up to 80% of AOSD cases can be controlled with corticosteroids; however, reports on those unresponsive to corticosteroids, conventional disease modifying drugs and biological agents, including anti-IL1 inhibitors, are emerging. We present a case of AOSD with severe poylarthritis unresponsive to corticosteroids, methotrexate, anakinra and etanercept, but successfully stabilised with a humanized monoclonal anti-IL-6 receptor antibody, tocilizumab, administered once monthly. Thereafter, we compare our case with case reports available in the literature and suggest that for anakinra refractive AOSD patients with arthritis, tocilizumab could be the drug of choice.
Authors:
Katja Perdan-Pirkmajer; Sonja Praprotnik; Matija Tomšič
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Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1465-7     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, University Medical Centre, Vodnikova 62, 1000 Ljubljana, Slovenia.
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