Document Detail

A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas.
MedLine Citation:
PMID:  21686999     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The present report concerns a patient with a malignant gastrin-producing neuroendocrine tumour (ie, Zollinger-Ellison syndrome) with recurrent hepatic gastrinomas, in whom no gastrinoma in the duodenum, pancreas or other extrahepatic sites could be identified despite the use of multiple, repeatedly performed imaging and exploration techniques over the past 20 years. A short review on primary liver gastrinomas published since 1981 is also given. Interestingly, our patient is the only case with documented recurrent gastrinoma in the liver. None of the cases in the literature had liver gastrinomas as part of the multiple endocrine neoplasia type I syndrome. The interpretation of hepatic gastrinomas as primary lesions is questionable unless comprehensive investigation and well documented long-term follow-up is performed.
Patricia Kuiper; Izak Biemond; Hein Verspaget; Cornelis Lamers
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Publication Detail:
Type:  Journal Article     Date:  2009-06-11
Journal Detail:
Title:  BMJ case reports     Volume:  2009     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2009  
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-11-10     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Leiden University Medical Center, Gastroenterology, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
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