Document Detail

A case of pulmonary adenocarcinoma accompanied by superior vena caval thrombosis in a patient with peutz-jeghers syndrome.
MedLine Citation:
PMID:  12411569     Owner:  NLM     Status:  MEDLINE    
A case of lung adenocarcinoma and extensive deep vein thrombosis in a patient with Peutz-Jeghers syndrome (PJS) is presented. A 31-year-old Chinese man complained of shoulder pain and swelling of the right arm. A series of diagnostic procedures revealed a primary adenocarcinoma in the left upper lobe with cervical and supraclavicular lymph node metastases accompanied by deep vein thrombosis in the superior vena cava and right jugular vein. In addition, typical pigmentation of the lips and oral mucosa and multiple hamartomas in the stomach, duodenum and colon led to the diagnosis of PJS. PJS is known to be associated with increased risk of malignancies, especially in the gastrointestinal tract, breast, genitals and pancreas. As bronchoscopic examination showed no hamartomatous lesions in the bronchi, the development of primary lung cancer in this young patient might be independent of any hamartomatous lesion and might be associated with some genetic factors relating to PJS.
Satoshi Hirano; Yuichi Takiguchi; Hidetoshi Igari; Kenzo Hiroshima; Masato Shingyoji; Reiko Watanabe; Tetsuro Moriya; Nobuhiro Tanabe; Koichiro Tatsumi; Takayuki Kuriyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  32     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2002-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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MeSH Terms
Adenocarcinoma / etiology*,  secondary
Genetic Predisposition to Disease
Intestinal Polyps / etiology,  pathology
Lung Neoplasms / etiology*,  pathology
Lymphatic Metastasis
Peutz-Jeghers Syndrome / complications*,  genetics
Superior Vena Cava Syndrome / etiology*

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