Document Detail

A case of progressive hypertension preceding gemcitabine-associated thrombotic microangiopathy complicated by acute kidney injury and stroke.
MedLine Citation:
PMID:  19814643     Owner:  NLM     Status:  MEDLINE    
Gemcitabine-associated thrombotic microangiopathy is being increasingly recognized as a serious complication of treatment. We report a normotensive patient who developed progressive hypertension after commencing gemcitabine therapy. She also developed subtle changes in her platelet count and serum creatinine months before her emergent presentation. Clinicians should be aware of new onset or worsening hypertension and 'mild' biochemical changes in gemcitabine-treated patients.
Paul J Phelan; Aaron Liew; Colm Magee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  31     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-09     Completed Date:  2010-01-05     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-4     Citation Subset:  IM    
Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland.
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MeSH Terms
Acute Kidney Injury / etiology*
Antineoplastic Agents / adverse effects*
Deoxycytidine / adverse effects,  analogs & derivatives*
Disease Progression
Hypertension / chemically induced*
Pancreatic Neoplasms / drug therapy*,  surgery
Stroke / etiology*
Thrombotic Microangiopathies / chemically induced*
Reg. No./Substance:
0/Antineoplastic Agents; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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