Document Detail

A case of portal vein thrombosis after laparoscopy-assisted splenectomy and cholecystectomy in a child.
MedLine Citation:
PMID:  17706514     Owner:  NLM     Status:  MEDLINE    
We report the case of an 8-year-old boy with a red cell membrane disorder who developed, soon after undergoing laparoscopic cholecystectomy and splenectomy, complete thrombosis of the right branch and a partial occlusion of the left branch of the portal vein. The child was affected by a right hemiparesis because of a hypoxic-ischemic disorder that occurred in the first hours of life and was heterozygous for the methylenetetrahydrofolate reductase gene mutation 677C-T. Intravenous heparin and aspirin were initiated on postoperative day 7. Heparin treatment was switched to the subcutaneous route after the first 24 hours. The symptoms subsided 3 days after the beginning of treatment, whereas complete resolution of portal vein thrombosis was observed 2 months later. A review of the literature is reported, and the possible pathogenetic mechanisms underlying portal vein thrombosis are discussed.
Enrica Rossi; Maria Elena Michelini; Caterina Borgna Pignatti; Fausto Zanotti; Andrea Franchella
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  42     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1449-51     Citation Subset:  IM    
Operative Unit of Pediatric Surgery, Arcispedale S. Anna, 44100 Ferrara, Italy.
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MeSH Terms
Anemia, Hemolytic, Congenital / surgery*
Anticoagulants / administration & dosage*
Aspirin / administration & dosage
Cholecystectomy, Laparoscopic / adverse effects*
Heparin / administration & dosage
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Portal Vein*
Splenectomy / adverse effects*
Venous Thrombosis / etiology*,  therapy
Reg. No./Substance:
0/Anticoagulants; 50-78-2/Aspirin; 9005-49-6/Heparin; EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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