Document Detail


A case of persistent left and absent right superior caval vein: An anatomical and embryological perspective.
MedLine Citation:
PMID:  20169608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relatively common persistent left superior caval vein (LSCV) is in most cases associated with doubling of the superior caval vein. A persistent LSCV with absent right superior caval vein (RSCV)-a rather rare event-was found during our course of gross anatomy. The LSCV drained into an enlarged coronary sinus, which was partly accompanied by an apparent "double" sinus of normal size draining into this enlarged coronary sinus. Histological and immunofluorescence studies using antibodies against smooth and cardiac muscle actins were performed. The terminal part of the LSCV near the opening into the right atrium contained cardiac actin as expected for a normal derivative of the left sinus horn. Previously only one case of doubled coronary sinus with LSCV has been reported and this abnormality was explained by splitting of the sinus. In our case, the partly doubled coronary sinus had the structure of coronary veins. Mechanical forces have been invoked for the obliteration of the LSCV. Therefore, we examined thirteen human embryos from 15 mm to 32 mm crown-rump length. In one embryo, we found a persistent LSCV together with an enormously enlarged left atrium. Contrary to previous suggestions our data indicate that during normal development a compression of the left anterior cardinal vein does not sufficiently explain the obliteration of the left and the persistence of the right vein. We therefore believe that beside a left dominated blood flow of head and arm, genes for left-right signaling may have to be taken into consideration.
Authors:
Monika Jacob; Andrea Sokoll; Hans Georg Mannherz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical anatomy (New York, N.Y.)     Volume:  23     ISSN:  1098-2353     ISO Abbreviation:  Clin Anat     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809128     Medline TA:  Clin Anat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-86     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy and Embryology, Ruhr University Bochum, Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Aged
Embryonic Development
Humans
Immunohistochemistry
Male
Muscle, Smooth, Vascular / metabolism
Vena Cava, Superior / embryology*,  metabolism
Chemical
Reg. No./Substance:
0/Actins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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