Document Detail


A case of penile squamous cell carcinoma treated with a combination of antiepidermal growth factor receptor antibody and chemotherapy.
MedLine Citation:
PMID:  24263192     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Our previous study showed that the features of epidermal growth factor receptor (EGFR)-RAS signaling in penile squamous cell carcinoma (SCC) suggested potential benefits of anti-EGFR monoclonal antibodies (mAbs) for penile SCC. Here, we report, for the first time, a combination of nimotuzumab (an EGFR mAb) with chemotherapy that resulted in a partial response in a 44-year-old patient with penile SCC, who developed bilateral inguinal node metastasis after primary partial penile amputation. The literature of case reports of anti-EGFR mAbs in penile SCC was also reviewed.
Authors:
Hai-Tao Men; Hong-Feng Gou; Meng Qiu; Jian-Ping He; Ke Cheng; Ye Chen; Jun Ge; Ji-Yan Liu
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  25     ISSN:  1473-5741     ISO Abbreviation:  Anticancer Drugs     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  123-125     Citation Subset:  -    
Affiliation:
Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
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