Document Detail


A case of pancreatic heterotopy of duodenal wall, intraductal papillary mucinous tumor and intraepithelial neoplasm of pancreas, papillary carcinoma of kidney in a single patient.
MedLine Citation:
PMID:  17168444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of the contemporaneous presence of two histologically different pancreatic neoplasms, one renal cancer and one embryogenic duodenal anomaly in a single patient. A 66-year-old man underwent ultrasound examination because of urinary disorders; a solid neoformation within the inferior pole of the left kidney was observed. Computed tomography confirmed the renal lesion, but also a heterogeneous mass within the pancreatic head appeared without bile ducts dilatation. Abdominal magnetic resonance revealed a multiloculated cystic component of the pancreatic mass. A second CT scan confirmed the renal and biliary findings, but it revealed a modest enlargement of the pancreatic asymptomatic mass. A resection of the left kidney inferior pole and a pylorus-preserving pancreaticoduodenectomy were performed. Histopathologic analysis of the surgical specimen revealed mild differentiated papillary renal carcinoma, intraductal papillary mucinous adenoma of the pancreatic head, foci of intraepithelial pancreatic neoplasm and pancreatic heterotopy of duodenal muscular and submucosal layers. The coexistence of several primaries and anomalies in one patient led us to suppose a genetic predisposition to different lesions, even in the absence of known familial genetic syndromes. The study of such cases may help to improve the investigation of molecular correlations and etiological factors of different solid tumors. Nowadays, surgery is the only effective cure.
Authors:
Cinzia Nobili; Claudio Franciosi; Luca Degrate; Roberto Caprotti; Fabrizio Romano; Elisa Perego; Rosangela Trezzi; Biagio Eugenio Leone; Franco Uggeri
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  92     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-12-15     Completed Date:  2006-12-28     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  455-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, San Gerardo Hospital, University of Milan-Bicocca, Monza, Italy. cinzia.nobi@libero.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Pancreatic Ductal* / diagnosis
Carcinoma, Papillary* / diagnosis
Carcinoma, Renal Cell / diagnosis
Choristoma* / diagnosis
Cystadenocarcinoma, Mucinous* / diagnosis
Duodenal Diseases* / diagnosis
Humans
Kidney Neoplasms* / diagnosis
Magnetic Resonance Imaging
Male
Neoplasms, Multiple Primary* / diagnosis
Nephrectomy / methods
Pancreas* / pathology
Pancreatic Neoplasms* / diagnosis
Pancreaticoduodenectomy
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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