Document Detail

A case of normal-pressure hydrocephalus associated with rheumatoid arthritis.
MedLine Citation:
PMID:  20440105     Owner:  NLM     Status:  MEDLINE    
Rheumatoid arthritis may cause central nervous system complications by means of various mechanisms. We describe the case of a patient with a new diagnosis of rheumatoid arthritis (RA) complicated by normal-pressure hydrocephalus. After treatment with prednisone, the patient improved remarkably as regards mental status, urinary control and gait. We suggest that normal-pressure hydrocephalus may occur as an extra-articular manifestation of RA, caused by a pathogenic inflammatory mechanism. We analyse previous case reports describing a relationship between RA and normal-pressure hydrocephalus, and discuss potential mechanisms underlying this association.
Chiara Catananti; Simona Mastropaolo; Cristina Calabrese; Maria Caterina Silveri; Graziano Onder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Aging clinical and experimental research     Volume:  22     ISSN:  1594-0667     ISO Abbreviation:  Aging Clin Exp Res     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132995     Medline TA:  Aging Clin Exp Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  189-91     Citation Subset:  IM    
Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Largo F. Vito 1, Rome, Italy.
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MeSH Terms
Activities of Daily Living
Anti-Inflammatory Agents / therapeutic use
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / complications*,  etiology
Brain / pathology
Cognition Disorders / complications,  drug therapy
Hydrocephalus, Normal Pressure / complications*
Magnetic Resonance Imaging
Methotrexate / therapeutic use
Prednisone / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antirheumatic Agents; 53-03-2/Prednisone; 59-05-2/Methotrexate

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