| A case of neuroleptic malignant syndrome induced by risperidone in a schizophrenic woman. | |
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MedLine Citation:
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PMID: 19442104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We report a case of neuroleptic malignant syndrome in a woman who assumed risperidone for schizoaffective disorders. CASE SUMMARY: A 45-year-old woman affected by schizoaffective disorders was admitted to Infectious Disease unit of Crotone Hospital because of a diagnosis of a fever of unknown origin. Clinical evaluation documented confusion and dysphoria, whereas chemical blood evaluation revealed acidosis and liver dysfunction. After few days she was transferred to the Operative Unit of Internal Medicine of San Giovanni in Fiore Hospital because of an increase in liver transaminases. Clinical evaluation showed the persistence of fever (38.8 degrees Celsius), with an increase in CPK, and liver enzymes. Pharmacological evaluation indicated a probable relationship between risperidone and NMS and led to a diagnosis of neuroleptic malignant syndrome associated with risperidone in a woman with schizophrenia. About seven days later, we recorded a complete resolution of her psychiatric symptoms. DISCUSSION: We postulate a possible interaction between risperidone and neuroleptic malignant syndrome and we suggest to use risperidone with caution in both young and middle aged people. |
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Authors:
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Luca Gallelli; Vincenzo Spagnuolo; Caterina Palleria; Giovambattista De Sarro; Maria Ferraro |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Current drug safety Volume: 4 ISSN: 1574-8863 ISO Abbreviation: - Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101270895 Medline TA: Curr Drug Saf Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 119-20 Citation Subset: IM |
Affiliation:
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Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University "Magna Graecia" of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy. luca_gallelli@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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adverse effects*,
therapeutic use Female Fever / chemically induced* Humans Middle Aged Neuroleptic Malignant Syndrome / etiology* Psychotic Disorders / drug therapy Risperidone / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 106266-06-2/Risperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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