| A case of nephrotic syndrome in a patient with Churg-Strauss syndrome. | |
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MedLine Citation:
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PMID: 19697037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal involvement in Churg-Strauss syndrome (CSS) is not uncommon, but nephrotic syndrome is rarely reported in patients with CSS. A 25-year-old woman with a long history of bronchial asthma presented to our hospital with a chief complaint of generalized edema. Laboratory studies revealed normocytic normochromic anemia, marked eosinophilia, positive anti-neutrophil cytoplasmic antibody, hypoalbuminemia, and hypercholesterolemia. Urinalysis showed heavy proteinuria (4+) without significant casts. The 24-hour urinary protein excretion was 6.5 g with a selective index of 0.35. Echocardiography and X-ray of the paranasal sinuses suggested restrictive cardiomyopathy and maxillary sinusitis, respectively. Diagnoses of CSS and nephrotic syndrome were made on the basis of clinical and laboratory findings. Renal biopsy was performed, and pathologic findings revealed focal segmental glomerulosclerosis with mesangiolysis. The patient's clinical symptoms and proteinuria improved markedly after combined treatment with corticosteroids and cyclophosphamide. Herein, we report a case of nephrotic syndrome in a patient with CSS. |
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Authors:
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Sun Young Park; Jae Hyun Chang; Hyun-Wook Kim; Dong Ki Kim; Eun Young Kim; Jung Tak Park; Tae Ik Chang; Jung Won Park; Hyeon Joo Jeong; Dae-Suk Han; Shin-Wook Kang |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-21 |
Journal Detail:
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Title: Rheumatology international Volume: 30 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 1385-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, College of Medicine, Brain Korea 21, Yonsei University, 134 Shinchon-Dong Seodaemoon-Gu, Seoul, 120-752, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Churg-Strauss Syndrome / complications*, drug therapy, pathology Cyclophosphamide / therapeutic use Drug Therapy, Combination Female Glomerular Mesangium / ultrastructure Glomerulosclerosis, Focal Segmental / complications, drug therapy, pathology Humans Immunosuppressive Agents / therapeutic use Nephrotic Syndrome / complications*, drug therapy, pathology Prednisolone / therapeutic use Proteinuria / complications, drug therapy, pathology Pulse Therapy, Drug Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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