| A case of nephrotic syndrome due to lupus nephritis which was controlled with low-density lipoprotein apheresis. | |
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MedLine Citation:
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PMID: 12460411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our report discusses a 29 year old female patient with nephrotic syndrome due to lupus nephritis, biopsy-proven World Health Organization classification Types IVb and V that was controlled with low-density lipoprotein (LDL) apheresis. She was initially treated with steroid therapy, including methylprednisolone pulse therapy, and the serological activity of her systemic lupus erythematosus was suppressed. However, her nephrotic state, accompanied by severe hyperlipidemia, persisted despite the steroid therapy. Since we could not obtain her consent to administer immunosuppressants such as cyclophosphamide, we tried to treat her using LDL apheresis (LDL-A). We found that her urine protein excretion, hyperlipidemia, hypoalbuminemia, and renal function improved following the initiation of LDL-A. This suggests that LDL-A may be an effective therapy for nephrotic syndrome due to lupus nephritis through short-term amelioration of hyperlipidemia. |
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Authors:
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Yuji Kamijo; Yoko Kaneko; Toru Ichikawa; Nobuhiko Kobayashi; Takayuki Koyama; Tetsuji Kakegawa; Hiroshi Kamijo; Keiichi Kono; Satoshi Minami; Naoki Tanaka; Hideo Arakura; Masayuki Hirata; Makoto Higuchi; Kendo Kiyosawa; Kazuhiko Hora |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Volume: 6 ISSN: 1091-6660 ISO Abbreviation: Ther Apher Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-03 Completed Date: 2003-03-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9706703 Medline TA: Ther Apher Country: United States |
Other Details:
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Languages: eng Pagination: 459-62 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Shinsu University School of Medicine, Matsumoto, Nagano, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Component Removal* Female Humans Lipoproteins, LDL / blood* Lupus Nephritis / complications* Nephrotic Syndrome / blood, etiology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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