|A case of native valve endocarditis caused by Burkholderia cepacia without predisposing factors.|
|Jump to Full Text|
|PMID: 21548997 Owner: NLM Status: MEDLINE|
|BACKGROUND: Infective endocarditis is rarely caused by Burkholderia cepacia. This infection is known to occur particularly in immunocompromised hosts, intravenous heroin users, and in patients with prosthetic valve replacement. Most patients with Burkholderia cepacia endocarditis usually need surgical treatment in addition to antimicrobial treatment.
CASE PRESENTATION: Here, we report the case of a patient who developed Burkholderia cepacia-induced native valve endocarditis with consequent cerebral involvement without any predisposing factors; she was successfully treated by antimicrobial agents only.
CONCLUSION: In this report, we also present literature review of relevant cases.
|Hyun Kyun Ki; Sung Hea Kim; Seong Woo Han; Hae Suk Cheong|
Related Documents :
|12648897 - Which neuroleptic would psychiatrists take for themselves or their relatives?
21980677 - Recurrent duodenal diverticulitis after surgical resection of the diverticulum: a case ...
|Type: Case Reports; Journal Article Date: 2011-05-08|
|Title: BMC infectious diseases Volume: 11 ISSN: 1471-2334 ISO Abbreviation: BMC Infect. Dis. Publication Date: 2011|
|Created Date: 2011-06-13 Completed Date: 2011-12-01 Revised Date: 2013-06-30|
Medline Journal Info:
|Nlm Unique ID: 100968551 Medline TA: BMC Infect Dis Country: England|
|Languages: eng Pagination: 114 Citation Subset: IM|
|Department of Medicine, School of Medicine, Konkuk University, Seoul 143-729, Korea. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Anti-Bacterial Agents / therapeutic use
Burkholderia cepacia / isolation & purification, physiology*
Endocarditis, Bacterial / drug therapy, microbiology*
Heart Valve Diseases / microbiology*
Journal ID (nlm-ta): BMC Infect Dis
Publisher: BioMed Central
Copyright ©2011 Ki et al; licensee BioMed Central Ltd.
Received Day: 7 Month: 9 Year: 2010
Accepted Day: 8 Month: 5 Year: 2011
collection publication date: Year: 2011
Electronic publication date: Day: 8 Month: 5 Year: 2011
Volume: 11First Page: 114 Last Page: 114
Publisher Id: 1471-2334-11-114
PubMed Id: 21548997
|A case of native valve endocarditis caused by Burkholderia cepacia without predisposing factors|
|Hyun Kyun Ki1||Email: email@example.com|
|Sung Hea Kim1||Email: firstname.lastname@example.org|
|Seong Woo Han1||Email: email@example.com|
|Hae Suk Cheong1||Email: firstname.lastname@example.org|
1Department of Medicine, School of Medicine, Konkuk University, Seoul 143-729, Korea
Burkholderia cepacia is a gram-negative bacillus. It is important nosocomial pathogen that particularly infects patients with cystic fibrosis  and chronic granulomatous diseases and is known to be resistant to many anti-bacterial agents.
Burkholderia cepacia rarely causes endocarditis in community settings, but it is known to cause infective endocarditis particularly in intravenous heroin users, and in patients with prosthetic valve replacement . However, infective endocarditis caused by Burkholderia cepacia in patients without predisposing factors is rare [4-6].
The treatment of Burkholderia cepacia endocarditis could be conservative, i.e., administration of antibacterial agents, and/or surgical modality [4-13]. According to the previous reports, most patients were prescribed trimethoprim-sulfamethoxazole and underwent valve surgery. Notwithstanding, the mortality in cases of infective endocarditis patients is not low despite the aggressive treatment of infective endocarditis .
Here, we report the case of a patient with Burkholderia cepacia endocarditis and cerebral involvement who had no predisposing factors, and the infection was successfully managed only by antimicrobial treatment. Along with this case, we also present a literature review.
A 77-year-old woman was transferred to our hospital from a local hospital for loss of consciousness and disorientation. She had experienced a fall 2 weeks before admission to our hospital. Plain spine radiography had revealed a spine compression fracture. Two days earlier, she was admitted to a local hospital for relief from back pain. However, during her stay at the hospital, she developed low grade fever, aphasia, and disorientation.
She was then transferred to our hospital for further evaluation of her symptoms that were suggestive of cerebral infarction. She denied any history of smoking, alcohol consumption, or intravenous drug use. She neither had cardiovascular disease nor exhibited any of the risk factors for it. Mild aphasia and hemianopsia were noted at neurological examination. Physical examination revealed a diastolic murmur at the mitral valve area.
The clinical manifestations were suggestive of mitral stenosis and cerebral infarction associated with emboli, which was considered the preliminary diagnosis. Echocardiography revealed mitral stenosis with a mobile 10-mm sized mobile mass (Figure 1). Brain magnetic resonance imaging (MRI) revealed subacute and chronic infarction in both the cerebral hemispheres and the cerebellum (Figure 2). On day 2 of hospitalization, fever above 38°C was noted; therefore, blood culture test was performed. She was administered ceftriaxone (2 g/d) and gentamicin (3 mg·kg-1.day-1) as an empirical treatment for infective endocarditis.
Despite the empirical antimicrobial treatment, intermittent low-grade fever was noted. Her blood culture was positive for Burkholderia cepacia, and antimicrobial susceptibility test yielded positive results for cefepime, ceftazidime, piperacillin, ciprofloxacin and trimethoprim-sulfamethoxazole (day 7 of hospitalization). Therefore, we changed the antimicrobial treatment to ceftazidime (6 g/d) from day 7.
Fever resolved completely from day 9, and blood culture was negative for Burkholderia cepacia. After 6 weeks of ceftazidime treatment, oral ciprofloxacin was prescribed for 2 weeks as an outpatient treatment.
After the antimicrobial treatment course was completed, infective endocarditis resolved completely; no relapse was noted during the follow-up period for 2 years.
Burkholderia cepacia, an opportunistic pathogen, is resistant to disinfectants and broad-spectrum antimicrobial agents. This pathogen often causes nosocomial infections in imunocompromised hosts, especially in patients with cystic fibrosis and chronic granulomatous diseases [3,4]. In addition, patients with cancer or chronic renal disease may also be susceptible to Burkholderia infection [14-16].
In these patients, central venous catheters are the primary source of bacteraemia . Burkholderia bacteremia also noted in patients undergoing haemodialysis . Burkholderia cepacia also causes infective endocarditis and skin and soft tissue pathology. This pathogen rarely causes infective endocarditis; however, there are some reports on the occurrence of this pathology in heroine addicts [4,10-13] and patients with prosthetic valves and valve replacements [3-5].
In our patients, Burkholderia cepacia had infected mitral valve despite the absence of predisposing factors that would make her susceptible to the infection. This case is different from the previous reports [3-13] in the following issues. First, most of the reported cases of Burholderia cepacia endocarditis involved the prosthetic valve. In contrast, native valve endocarditis was relatively less frequent [3,4,7-9]. Burholderia cepacia-induced native valve endocarditis has rarely been reported. As a predisposing condition, most patients with native valve endocarditis had a history of intravenous drug abuse [3,4,7-9] and mitral valve endocarditis has mostly been reported in patients having prosthetic valves [3-5]. However, our patient did not exhibit any of the predisposing factors related to this infection described previously.
Second, trimethoprim-sulfamethoxazole is commoly used for the treatment of this infection [4-9]. However, ceftazidime was administered to our patient because of cerebral involvement and risk of trimethoprim-sulfamethoxazole allergy. Brain MRI had revealed cerebral and cerebellar infarctions in our patient. These findings suggest that the emboli had migrated into the cerebral hemispheres and induced an ischemic change of the involved regions. Therefore, an antimicrobial agent, such as ceftazidime, that could penetrate the blood-brain barrier was required in this case.
Antimicrobial resistance of Burkholderia cepacia has posed a great challenge of treating the infection. This pathogen is intrinsically resistant to aminoglycosides and polymyxins. The antimicrobial effective against this pathogen are carbapenem, broad-spectrum beta-lactams (such as, piperacillin-tazobactam and ceftazidime), and trimethoprim-sulfamethoxazole. Therefore, because of such antimicrobial resistance, a combination of drugs and surgical treatment for valvulopathy is required [3-7,9]. However, we successfully treat the patient without the surgical treatment.
Third, replacement of the prosthetic or native valve has been required in most patients with infective endocarditis [3,7-9] but we did not need to perform any such surgery in our patient because of the excellent response to antimicrobial therapy. In addition, her valve function was also apparently preserved without surgery. On the bases of her valve function, life expectancy, and the morbidity involved in such surgical treatment, we decided against surgery and we were able to successfully treat the infective endocarditis by antibiotics only.
Fourth, in patients with Burkholderia cepacia endocarditis, the mitral valve is known to be less frequently involved than the tricuspid valve; mitral valve involvement has been reported in only those patients who previously had prosthetic valve replacement or valve repair surgery [3-5], and only 1 study reported aortic valve endocarditis without any predisposing factors .
In summary, we experienced a case of native valve endocarditis with cerebral involvement by Burkholderia cepacia without predisposing factors of Burkholderia infection, successfully managed by antimicrobial treatment only.
Infective endocarditis is rarely caused by Burkholderia cepacia. Recently, we encountered a patient who developed Burkholderia cepacia endocarditis and cerebral involvement without the predisposing factors. We successfully treated the patient with only antimicrobial medication; surgical modality was not required.
Written informed consent was obtained from the patient for publication of this case report and the accompanying images. A copy of the written consent is available for review by the Editor of this journal.
The authors declare that they have no competing interests.
HKK drafted this manuscript. SHK and SWH managed the patient. HSC revised this manuscript. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
We thank the patient for giving consent to publish their clinical details and the clinical photographs. Also we thank Jong Sun Ok (nurse) for helping us.
|Tablan OC,Chorba TL,Schidlow DV,White JW,Hardy KA,Gilligan PH,Morgan WM,Carson LA,Martone WJ,Jason JM,Jarvis WR,Pseudomonas cepacia colonization in patients with cystic fibrosis: risk factors and clinical outcomeJ PediatrYear: 198510738238710.1016/S0022-3476(85)80511-44032134|
|Bottone EJ,Douglas SD,Rausen AR,Keusch GT,Association of Pseudomonas cepacia with chronic granulomatous diseaseJ Clin MicrobiolYear: 197514254281176612|
|Aggarwal N,Garg S,Pannu HS,Kler TS,Fatal Burkholderia cepacia early prosthetic valve endocarditis: a very rare case and a review of the literatureJ Heart Valve DisYear: 20051427127415792192|
|Noriega ER,Rubinstein E,Simberkoff MS,Rahal JJ,Subacute and acute endocarditis due to Pseudomonas cepacia in heroin addictsAm J MedYear: 197559293610.1016/0002-9343(75)90318-6166559|
|Speller DC,Pseudomonas cepacia endocarditis treated with co-trimoxazole and kanamycinBr Heart JYear: 197335474810.1136/hrt.35.1.474685906|
|Welch DF,Muszynski MJ,Pai CH,Marcon MJ,Hribar MM,Gilligan PH,Matsen JM,Ahlin PA,Hilman BC,Chartrand SA,Selective and differential medium for recovery of Pseudomonas cepacia from the respiratory tracts of patients with cystic fibrosisJ Clin MicrobiolYear: 198725173017343654943|
|Goldmann DA,Klinger JD,Pseudomonas cepacia: biology, mechanisms of virulence, epidemiologyJ PediatrYear: 198610880681210.1016/S0022-3476(86)80749-13517271|
|Isles A,Maclusky I,Corey M,Gold R,Prober C,Fleming P,Levison H,Pseudomonas cepacia infection in cystic fibrosis: an emerging problemJ PediatrYear: 198410420621010.1016/S0022-3476(84)80993-26420530|
|van Pelt C,Verduin CM,Goessens WH,Vos MC,Tummler B,Segonds C,Reubsaet F,Verbrugh H,van Belkum A,Identification of Burkholderia spp. in the clinical microbiology laboratory: comparison of conventional and molecular methodsJ Clin MicrobiolYear: 1999372158216410364579|
|Neu HC,Garvey GJ,Beach MP,Successful treatment of Pseudomonas cepacia endocarditis in a heroin addict with trimethoprim-sulfamethoxazoleJ Infect DisYear: 1973128Suppl76877010.1093/infdis/128.Supplement_3.S7684758058|
|Hamilton J,Burch W,Grimmett G,Orme K,Brewer D,Frost R,Fulkerson C,Successful treatment of Pseudomonas cepacia endocarditis with trimethoprim-sulfamethoxazoleAntimicrob Agents ChemotherYear: 197345515544791489|
|Rahal JJ Jr,Simberkoff MS,Hyams PJ,Pseudomonas cepacia tricuspid endocarditis: treatment with trimethoprim, sulfonamide, and polymyxin BJ Infect DisYear: 1973128Suppl76276710.1093/infdis/128.Supplement_3.S7624357095|
|Mandell IN,Feiner HD,Price NM,Simberkoff M,Pseudomonas cepacia endocarditis and ecthyma gangrenosumArch DermatolYear: 197711319920210.1001/archderm.113.2.199836696|
|Mann T,Ben-David D,Zlotkin A,Shachar D,Keller N,Toren A,Nagler A,Smollan G,Barzilai A,Rahav G,An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patientsInfectionYear: 20103818719410.1007/s15010-010-0017-020358245|
|Martino R,Gomez L,Pericas R,Salazar R,Sola C,Sierra J,Garau J,Bacteraemia caused by non-glucose-fermenting gram-negative bacilli and Aeromonas species in patients with haematological malignancies and solid tumoursEur J Clin Microbiol Infect DisYear: 20001932032310.1007/s10096005048510834826|
|Kaitwatcharachai C,Silpapojakul K,Jitsurong S,Kalnauwakul S,An outbreak of Burkholderia cepacia bacteremia in hemodialysis patients: an epidemiologic and molecular studyAm J Kidney DisYear: 20003619920410.1053/ajkd.2000.829510873892|
Keywords: Burkholderia cepacia, Endocarditis, Native valve.
Previous Document: Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with ...
Next Document: PLAYgrounds: effect of a PE playground program in primary schools on PA levels during recess in 6 to...