Document Detail

A case of multiple endocrine neoplasia type 1 with primary liver gastrinoma.
MedLine Citation:
PMID:  20514321     Owner:  NLM     Status:  MEDLINE    
Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN 1). Primary hepatic gastrinomas in MEN 1 are very rare, with no previous reports published in the literature. We reported the case of a 39 yr old female patient with a history of repeated peptic ulcers and a hypoglycemia episode. Abdominal CT indicated a well-defined liver mass and a pancreatic head mass. Somatostatin-receptor scintigraphy with [(111)In] DTPA octreotide demonstrated a strong uptake of the radiotracer in the left lateral segment at the site of the hepatic mass. After operation, immunohistochemical staining was consistent with pancreatic insulinoma and primary hepatic gastrinoma. As the liver is a common site of metastases from gastrinoma, primary liver gastrinoma has not yet been reported with MEN 1. We diagnosed this patient using immunohistochemical studies and treated this patient by hepatic segmentectomy.
Sul Ra Lee; Moon Chan Choi; Kyu Jeung Ahn
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-25
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  953-6     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
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MeSH Terms
Gastrinoma / complications,  diagnosis*,  pathology
Hypoglycemia / etiology
Insulinoma / complications,  diagnosis,  pathology
Liver Neoplasms / complications,  diagnosis*,  pathology
Mastectomy, Segmental
Multiple Endocrine Neoplasia Type 1 / complications,  diagnosis*
Pancreatic Neoplasms / complications,  diagnosis,  pathology
Peptic Ulcer / etiology
Tomography, X-Ray Computed

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