Document Detail

A case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) with treatment-resistant status epilepticus that was effectively treated with lamotrigine.
MedLine Citation:
PMID:  24225564     Owner:  NLM     Status:  In-Data-Review    
A 16-year-old woman with MELAS developed fever and myoclonic epilepsy which improved with conventional anti-epileptic drugs. Since seizures recurred one month after successful treatment, the doses of phenobarbital, clonazepan, and valproate were increased. However, there was no improvement and status epilepticus continued. The addition of lamotrigine resulted in a decreased frequency and good control of seizures. This case is important, showing satisfactory results from the addition of lamotrigine for treatment-resistant status epilepticus.
Toru Kai; Shuichiro Masuda; Hiroyasu Tokunaga; Shigeaki Hayashi; Tatsui Nagado; Yoshikazu Maruyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rinshō shinkeigaku = Clinical neurology     Volume:  53     ISSN:  1882-0654     ISO Abbreviation:  Rinsho Shinkeigaku     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417466     Medline TA:  Rinsho Shinkeigaku     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  809-13     Citation Subset:  IM    
Department of Neurology, Imakiire General Hospital.
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