| A case of microscopic polyangiitis associated with aortic valve insufficiency. | |
| | |
MedLine Citation:
|
PMID: 21120499 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Microscopic polyangiitis (MPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by inflammation of small-sized vessels. Although there have been some reports of ANCA-associated vasculitis presenting as aortitis syndrome, MPA rarely involves large-sized vessels such as the aorta. We report an unusual case of MPA combined with severe acute aortic valve insufficiency in a 56-year-old man. He initially presented with prolonged fever, skin rash, and rapidly progressive glomerulonephritis. P-ANCA and anti-myeloperoxidase (MPO) antibodies were positive, but the c-ANCA and anti-proteinase-3 antibodies were negative. Skin biopsy of the lower leg showed necrotizing arteritis. Kidney biopsy was also performed, which revealed diffuse necrotizing and crescentic glomerulonephritis (GN) consistent with pauci-immune ANCA-associated GN. Serial echocardiographic evaluations revealed aortic valve changes and worsening acute aortic valve insufficiency over a two-month period. Despite intensive treatment, our patient developed sudden cardiac arrest and died. Our patient demonstrated typical clinical features and histopathologic findings for systemic vasculitis and had a positive anti-MPO antibody, all of which were consistent with the diagnosis of MPA. Thus, MPA may have been the cause of acute aortic valve insufficiency in this case. |
| | |
Authors:
|
Bae Keun Kim; So-Yeon Park; Chan-Bum Choi; Tae-Hwan Kim; Jae-Bum Jun; Se Min Jang; Moon Hyang Park; Wan-Sik Uhm |
Related Documents
:
|
1920649 - Duplex ultrasound criteria for diagnosis of splanchnic artery stenosis or occlusion. 8866909 - Endothelial function of the mesenteric arteriole and mechanical behaviour of the caroti... 18057299 - Implantation of a port-catheter system through the superior mesenteric artery for repea... 7362459 - Splanchnic arteriosclerotic disease and intestinal angina. 15897619 - A simple method of intestinal anastomosis (ileocolostomy) in rats. 20623119 - Life-threatening lower gastrointestinal bleeding in a 2-year-old boy treated by transca... 19716729 - The prevalence of carotid artery calcifications detected on panoramic radiographs in pa... 6883499 - Noninvasive ergonovine maleate provocative testing for coronary artery spasm: the need ... 10678369 - The aortic valve blood supply. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-1 |
Journal Detail:
|
Title: Rheumatology international Volume: - ISSN: 1437-160X ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine, #17 Haengdang-dong, Seongdong-gu, Seoul, 133-792, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The treatment of rheumatoid arthritis during pregnancy.
Next Document: Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN...