| A case of micrographia after subcortical infarction: possible involvement of frontal lobe function. | |
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MedLine Citation:
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PMID: 12940845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most reports of micrographia associated with focal brain lesions have related this finding to damage in the left basal ganglia. Here we describe the case of a 68-year-old man presenting with reversible micrographia accompanied by hypophonia in the absence of extrapyramidal signs after cerebral infarction in the left subcortical region. At the time of the patient's admission, diffusion-weighted magnetic resonance imaging sequence showed the lesion to principally involve the corona radiata, with some involvement of the putamen. Neurologically, mild right-sided brachiofacial hemiparesis and grasp reflexes - a frontal lobe sign - were observed. As his micrographia and hypophonia improved, the patient's grasp reflexes improved in parallel. In addition, recovery of regional cerebral blood flow in the left frontal lobe was confirmed by single photon emission computed tomography (technetium-99 m HMPAO). The present case suggests the possibility that the function of frontal-subcortical circuit might also be involved in the production and improvement of micrographia and that micrographia and hypophonia may share a common pathophysiology. |
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Authors:
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M Nakamura; M Hamamoto; S Uchida; H Nagayama; S Amemiya; S Okubo; K Tanaka |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 10 ISSN: 1351-5101 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-27 Completed Date: 2003-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 593-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan. motoaki@motoaki.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebral Infarction / complications, pathology* Dysarthria / etiology, pathology Frontal Lobe / pathology* Handwriting* Humans Magnetic Resonance Imaging / methods Male |
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