Document Detail

A case of methemoglobinemia after ingestion of an aphrodisiac, later proven as dapsone.
MedLine Citation:
PMID:  10487144     Owner:  NLM     Status:  MEDLINE    
Methemoglobin (MetHb) is an oxidation product of hemoglobin in which the sixth coordination position of ferric iron is bound to a water molecule or to a hydroxyl group. The most common cause of acquired MetHb-emia is accidental poisoning which usually is the result of ingestion of water containing nitrates or food containing nitrite, and sometimes the inhalation or ingestion of butyl or amyl nitrite used as an aphrodisiac. We herein report a case of MetHb-emia after ingestion of an aphrodisiac, later identified as dapsone by gas chromatograph/mass selective detector (GC/MSD). A 24-year old male was admitted due to cyanosis after ingestion of a drug purchased as an aphrodisiac. On arterial blood gas analysis, pH was 7.32, PaCO2 26.8 mmHg, PaO2 75.6 mmHg, and bicarbonate 13.9 mmol/L. Initial pulse oxymetry was 89%. With 3 liter of nasal oxygen supplement, oxygen saturation was increased to 90-92%, but cyanosis did not disappear. Despite continuous supplement of oxygen, cyanosis was not improved. On the fifth hospital day, MetHb was 24.9%. Methylene blue was administered (2 mg/kg intravenously) and the patient rapidly improved. We proved the composition of aphrodisiac as dapsone by the method of GC/MSD.
S W Lee; J Y Lee; K J Lee; M Kim; M J Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Yonsei medical journal     Volume:  40     ISSN:  0513-5796     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  388-91     Citation Subset:  IM    
Department of Internal Medicine, Inha University College of Medicine, Inchon, Korea.
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MeSH Terms
Administration, Oral
Antidotes / therapeutic use
Aphrodisiacs / adverse effects*
Cyanosis / blood,  chemically induced,  drug therapy
Dapsone / adverse effects*
Methemoglobinemia / chemically induced*,  drug therapy
Methylene Blue / therapeutic use
Reg. No./Substance:
0/Antidotes; 0/Aphrodisiacs; 61-73-4/Methylene Blue; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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