Document Detail

A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis.
MedLine Citation:
PMID:  18793567     Owner:  NLM     Status:  MEDLINE    
Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell hyperactivity, which results in production of autoantibodies and immune complexes. SS can exist as a primary disorder or in association with other autoimmune processes. A usually mild, proximal and insidious inflammatory myopathy can occur in patients with SS with a broad clinical and pathological spectrum. Interstitial nephritis with mild proteinuria and tubular dysfunction is the most common renal manifestation of SS, but glomerular involvement due to immune complex deposition may also rarely occur [Goules et al. 2000]. There is an association of SS with hepatic abnormalities, as evidenced by abnormal liver biochemical tests or histological characteristics of primary biliary cirrhosis (PBC), portal tract fibrosis, or autoimmune hepatitis [Abraham et al. 2004]. The pathogenetic mechanism of liver involvement in SS is not clear, but it is possible that hepatic and salivary gland damage share a similar pathology. The combination of Sjögren syndrome with kidney, liver and muscle involvement in one entity is extremely rare and data in the literature are remarkably sparse. We present a case of a 43-year-old female patient suffering from SS accompanied by polymyositis, membranous nephropathy and autoimmune hepatitis.
I Stefanidis; M Giannopoulou; V Liakopoulos; S Dovas; F Karasavvidou; K Zachou; G K Koukoulis; G N Dalekos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  70     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  245-50     Citation Subset:  IM    
Department of Nephrology, University of Thessaly, Larissa, Greece.
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MeSH Terms
Glomerulonephritis, Membranous / complications*
Hepatitis, Autoimmune / complications*
Polymyositis / complications*
Sjogren's Syndrome / complications*

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