Document Detail

A case of maternal herpes simplex virus encephalitis during late pregnancy.
MedLine Citation:
PMID:  19129790     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A pregnant 25-year-old woman at 32 weeks' gestation was admitted to an emergency unit after her husband had found her drowsy and with her tongue bitten. The day before admission, the patient had developed a fever of 39 degrees C, was suffering from headaches, was nauseated and had vomited. On admission, she had anterograde and retrograde amnesia, but no somatic neurological deficits were detected.
INVESTIGATIONS: Routine laboratory testing, lumbar puncture, cerebrospinal fluid analysis, routine bacteriology, brain MRI, and polymerase chain reaction testing for neurotropic viruses including herpes simplex virus types 1 and 2.
DIAGNOSIS: Maternal herpes simplex virus type 1 encephalitis.
MANAGEMENT: Antiviral and anticonvulsive therapy, supportive treatment, and cesarean section.
Johann Sellner; Roberto Buonomano; Krassen Nedeltchev; Oliver Findling; Gerhard Schroth; Daniel V Surbek; Stephen L Leib
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nature clinical practice. Neurology     Volume:  5     ISSN:  1745-8358     ISO Abbreviation:  Nat Clin Pract Neurol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-08     Completed Date:  2009-03-03     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  101261799     Medline TA:  Nat Clin Pract Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Department of Neurology, Klinikum rechts der Isar at the Technical University of Munich, Munich, Germany.
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MeSH Terms
Acyclovir / therapeutic use
Anticonvulsants / therapeutic use
Antiviral Agents / therapeutic use
Brain / pathology,  virology
Encephalitis, Herpes Simplex / drug therapy,  pathology,  physiopathology*
Herpesvirus 1, Human
Magnetic Resonance Imaging
Pregnancy Complications, Infectious / drug therapy,  physiopathology*,  virology*
Seizures / prevention & control,  virology
Triazines / therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 0/Antiviral Agents; 0/Triazines; 59277-89-3/Acyclovir; U3H27498KS/lamotrigine

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