Document Detail

A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection.
MedLine Citation:
PMID:  20227583     Owner:  NLM     Status:  MEDLINE    
Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm with histopathologic similarities to nasopharyngeal carcinoma. The association of nasopharyngeal carcinoma with Epstein-Barr virus (EBV) is well documented. EBV has also been reported to be associated with LELC in only four sites (the stomach, salivary glands, lung, and thymus), but not in the skin. We report herein a case of EBV-positive LELCS. An 82-year-old female presented with a red nodule on the right cheek. Histologically, the entire dermis was occupied by atypical tumor cell nests with dense lymphocytic infiltration. Neoplastic cells were strongly positive for cytokeratin 14 but were negative for cytokeratins 19 and 20. EBV genomes in neoplastic cells were detected by polymerase chain reaction analysis and in situ hybridization for EBV-encoded RNA, suggesting an association with EBV.
Rui Aoki; Hiroshi Mitsui; Kazutoshi Harada; Tatsuyoshi Kawamura; Naotaka Shibagaki; Katsuhiko Tsukamoto; Shin-ichi Murata; Shinji Shimada
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  62     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-4     Citation Subset:  IM    
Copyright Information:
Copyright 2008 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma / complications*,  virology*
Epstein-Barr Virus Infections / complications*
Herpesvirus 4, Human / isolation & purification*
Skin Neoplasms / complications*,  virology*

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