| A case of lymphocytic infundibuloneurohypophysitis associated with systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 12625409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 27-year-old man was admitted to our hospital with facial erythema and general malaise. He had previously suffered from orbital myositis, central diabetes insipidus (DI), peripheral neuritis, and hypogonadotropic hypogonadism. Physical and immunological examinations revealed that he was suffering from systemic lupus erythematosus (SLE). Magnetic resonance imaging of the hypothalamic-pituitary region demonstrated a significant enlargement of the pituitary stalk and posterior pituitary. Endocrinological examinations showed that he had not only DI and hypogonadotropic hypogonadism but also hypoadrenalism and hypothyroidism, which were ascribed to the pituitary stalk lesion. Lymphocytic infundibuloneurohypophysitis associated with SLE was diagnosed. Administration of 30 mg/day of prednisolone for one month resulted in a marked reduction of the pituitary stalk thickening and posterior pituitary. It is recommended that a pharmacological dose of glucocorticoid be used in the treatment of lymphocytic hypophysitis patients who show significant thickening of the pituitary stalk and/or a large pituitary mass. |
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Authors:
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Kozo Hashimoto; Koichi Asaba; Kanae Tamura; Toshihiro Takao; Toshihiro Nakamura |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Endocrine journal Volume: 49 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-03-10 Completed Date: 2003-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 605-10 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Insufficiency
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diagnosis,
etiology Adult Diabetes Insipidus / complications, diagnosis Humans Hypogonadism / diagnosis, etiology Hypothalamic Diseases / complications*, diagnosis, drug therapy Hypothyroidism / diagnosis, etiology Lupus Erythematosus, Systemic / complications*, diagnosis Lymphocytes / pathology Male Pituitary Diseases / complications*, diagnosis, drug therapy Pituitary Gland, Anterior / pathology Pituitary Gland, Posterior / pathology Prednisolone / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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