Document Detail

A case of isodicentric 7p as sole abnormality in a patient with acute myeloid leukemia.
MedLine Citation:
PMID:  8697419     Owner:  NLM     Status:  MEDLINE    
The detection of isochromosomes in the leukemias and in solid tumors has been well described in the literature, the most common being the i(17q), which is found in the blast crisis of CML and terminal stages of acute myeloid leukemia. Reports of isochromosome 7 have, however, been less well represented, particularly isochromosomes of the short arm of chromosome 7, which represent approximately 1% of all reported isochromosomes in neoplasia. We present here a case report of an elderly female patient with AML-M2 who manifested an idic(7p) in the majority of her bone marrow cells. Fluorescence in situ hybridization (FISH) studies with both centromere-7--and chromosome-7--specific DNA probes verified the diagnosis of idic(7p). To the best of our knowledge, this is the first report of this type of leukemia with an acquired idic(7p) as the sole cytogenetic abnormality.
G C Beverstock; P H de Meijer; D ten Bokkel Huinink; J F Pruijt; G J den Ottolander; H W Wessels; P Mollevanger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  89     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-30     Completed Date:  1996-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Department of Clinical Cytogenetics, University Hospital Leiden, The Netherlands.
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MeSH Terms
Aged, 80 and over
Bone Marrow / ultrastructure
Chromosomes, Human, Pair 7*
DNA Probes
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*
Reg. No./Substance:
0/DNA Probes

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