Document Detail

[A case of ischemic skin necrosis after glypressin therapy in liver cirrhosis]
MedLine Citation:
PMID:  18604141     Owner:  NLM     Status:  MEDLINE    
Terlipressin is a synthetic analogue of vasopressin, which has been used in the treatment of acute variceal hemorrhage. In contrast to vasopressin, terlipressin can be administered as intermittent injections instead of continuous intravenous infusion. Thus, it has a less adverse reaction than vasopressin. We report a case of ischemic skin complication in a cirrhotic patient treated with terlipressin. A 71-year-old man with liver cirrhosis was admitted because of hematemesis and melena. He was commenced on terlipressin at a dose 1 mg every 6 hours for the treatment of varicieal bleeding. After 36 hours of treatment, skin blistering and ecchymosis was noted on the skin of his upper thigh, scrotal area and trunk. We found that terlipressin was a possible cause of ischemic skin complication based on the skin biopsy finding. Terlipressin may induce a complication of the ischemic event. In spite of rarity, special attention needs to paid on the peripheral ischemic complication of terlipressin.
Ji Eun Oh; Jung Soo Ha; Dae Hyeon Cho; Gil Jong Yu; Sang Goon Shim
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi     Volume:  51     ISSN:  1598-9992     ISO Abbreviation:  Korean J Gastroenterol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-09-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101189416     Medline TA:  Korean J Gastroenterol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM    
Department of Internal Medicince, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Fatal Outcome
Hematemesis / diagnosis
Hemorrhage / drug therapy
Ischemia / chemically induced*,  pathology*
Liver Cirrhosis / complications*
Lypressin / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Melena / diagnosis
Skin / blood supply*,  drug effects,  pathology*
Vasoconstrictor Agents / administration & dosage,  adverse effects*,  therapeutic use
Reg. No./Substance:
0/Vasoconstrictor Agents; 14636-12-5/terlipressin; 50-57-7/Lypressin

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