Document Detail

A case in which coronary spasms were induced by ergonovine provocation at the sites of coronary artery ectasia.
MedLine Citation:
PMID:  2287843     Owner:  NLM     Status:  MEDLINE    
We experienced a patient in whom coronary spasms were induced by an ergonovine provocation test during coronary angiography at the sites of coronary artery ectasia. The patient was a 45-year-old male with chest pain at rest, which promptly disappeared when given sublingual nitroglycerin. Similar attacks occurred frequently even with the administration of drugs after admission, but no significant changes were observed in electrocardiography (ECG) during the attacks or by repeated Holter ECG. The results of exercise ECG and provocation tests such as Valsalva maneuver, hyperventilation, and cold pressor test were negative. Coronary angiography showed ectatic changes in the left coronary artery, and the coronary spasms were induced by ergonovine administration at the ectatic portion of the left anterior descending artery and left circumflex artery, and right coronary artery with chest symptoms similar to those observed during spontaneous attacks. However, there were no significant changes in ECG. This rare case suggests an involvement of spasms in the pathogenic mechanism of myocardial ischemia in coronary artery ectasia.
J Segawa; K Ninomiya; H Nandate; Y Nakashima; A Kuroiwa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of UOEH     Volume:  12     ISSN:  0387-821X     ISO Abbreviation:  J. UOEH     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-27     Completed Date:  1991-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909645     Medline TA:  J UOEH     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  439-47     Citation Subset:  IM    
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Coronary Angiography
Coronary Disease / complications*
Coronary Vasospasm / chemically induced*
Dilatation, Pathologic
Ergonovine / adverse effects*,  diagnostic use
Middle Aged
Reg. No./Substance:

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