Document Detail


A case of idiopathic nodular glomerulosclerosis mimicking diabetic glomerulosclerosis (Kimmelstiel-Wilson type).
MedLine Citation:
PMID:  12092775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of idiopathic nodular glomerulosclerosis mimicking diabetic Kimmelstiel-Wilson glomerulopathy is reported. The patient was a 45-year-old man suffering from nephrotic syndrome. Light and electron microscopy revealed diffuse and nodular glomerulosclerosis indistinguishable from diabetic nodular glomerulosclerosis. Diabetes mellitus, however, had been excluded both by extensive clinical and by laboratory investigation. The differential diagnosis also included amyloidotic and non-amyloidotic fibrillary glomerulopathy, light chain glomerulopathy, collagen type III disease, immunotactoid glomerulopathy, and the sclerosing variant of membranoproliferative glomerulonephritis. Immunohistochemistry and ultrastructural investigations, however, excluded these entities, and the diagnosis of idiopathic nodular glomerulosclerosis was made. This variant has to be included in the differential diagnosis of nodular glomerulopathy associated with nephrotic syndrome.
Authors:
J Müller-Höcker; M Weiss; G H Thoenes; A Grund; A Nerlich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  198     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  375-9     Citation Subset:  IM    
Affiliation:
Pathologisches Institut, Ludwig-Maximilians-Universität, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amyloidosis / pathology
Collagen Diseases / pathology
Collagen Type III
Diabetic Nephropathies / metabolism,  pathology*
Diagnosis, Differential
Fluorescent Antibody Technique, Indirect
Glomerular Mesangium / ultrastructure
Glomerulonephritis / pathology
Glomerulonephritis, Membranous / pathology
Glomerulosclerosis, Focal Segmental / metabolism,  pathology*
Humans
Immunohistochemistry
Kidney Glomerulus / pathology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Collagen Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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