| A case of hypothyroid Graves' disease following external radiation therapy to the cervical region. | |
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MedLine Citation:
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PMID: 16714839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of hypothyroid Graves' disease occurred following external radiation therapy to the cervical region is described. Severe hypothyroidism developed in a 56-year-old man 6 months after external radiation therapy for submandibular cancer. Serological evaluation of thyroid autoimmunity revealed the presence of antithyroid antibodies and thyrotropin-binding inhibitory immunogloblins (TBII). Diplopia, limitation of downward gaze, and palpebral edema developed 2 years after levothyroxine replacement therapy. Ocular magnetic resonance imaging revealed marked hypertrophy of the bilateral extraocular muscles with signal hyperintensity on T2-weighted images. This infiltrative ophthalmopathy showed marked improvement after additional treatment with high-dose methylprednisolone and orbital radiation, in parallel with a decrease in TBII. These results suggest that radiation-associated thyroidal injury might be associated with the etiology of hypothyroid Graves' disease. |
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Authors:
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Eijun Nishihara; Shuji Fukata; Nobuhiko Kimura; Masahiro Hagihara; Takumi Kudo; Hidemi Ohye; Mitsuru Ito; Sumihisa Kubota; Nobuyuki Amino; Kanji Kuma; Akira Miyauchi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-05-20 |
Journal Detail:
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Title: Endocrine journal Volume: 53 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-27 Completed Date: 2006-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 357-61 Citation Subset: IM |
Affiliation:
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Kuma Hospital, Kobe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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radiotherapy Diplopia / etiology, ultrasonography Graves Disease / diagnosis*, etiology* Graves Ophthalmopathy / etiology Humans Hypothyroidism / diagnosis*, etiology* Male Middle Aged Radiation Injuries / etiology* Radiotherapy / adverse effects* Submandibular Gland Neoplasms / radiotherapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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