| A case of hypothalamic panhypopituitarism with empty sella syndrome: case report and review of the literature. | |
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MedLine Citation:
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PMID: 19352054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Empty sella syndrome is frequently accompanied with pituitary dysfunction. Most of the patients with empty sella syndrome demonstrate primary pituitary or stalk dysfunction and few cases show hypothalamic dysfunction. A 71-year-old man manifested appetite loss, nausea and vomiting with hyponatremia and adrenal insufficiency. Hormonal evaluation and cranial MRI revealed a panhypopituitarism with empty sella. Intriguingly, while the response of ACTH to CRH administration was exaggerated, the response to insulin hypoglycemia was blunted. Serum PRL levels were normal. Further, decreased level of fT4, slightly elevated basal levels of TSH, and delayed response of TSH to TRH administration were observed. These findings strongly suggest that the panhypopituitarism is caused by hypothalamic dysfunction. The presence of autoantibodies to pituitary and cerebrum in the patient's serum implies an autoimmune mechanism as a pathogenesis. |
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Authors:
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Hisako Komada; Masaaki Yamamoto; Saki Okubo; Kanto Nagai; Keiji Iida; Takehiro Nakamura; Yushi Hirota; Kazuhiko Sakaguchi; Masato Kasuga; Yutaka Takahashi |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-04-07 |
Journal Detail:
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Title: Endocrine journal Volume: 56 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-31 Completed Date: 2009-10-26 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 585-9 Citation Subset: IM |
Affiliation:
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Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate school of Medicine, Kobe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Empty Sella Syndrome / etiology* Encephalitis, Herpes Simplex / complications Humans Hypopituitarism / complications* Hypothalamus / physiopathology Male Thyrotropin-Releasing Hormone / diagnostic use |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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