Document Detail


A case of hyperreninemic hypertension with bilateral positive captopril renography but without renovascular stenosis.
MedLine Citation:
PMID:  18360059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 34-year-old woman was admitted to our hospital because of hypertension with hypokalemia. Her past medical history revealed that at age 24 she had been diagnosed with left renal lithiasis and had undergone extracorporeal shock-wave lithotripsy (ESWL). Physical examination showed that her peripheral pulses were intact and no peripheral edema or audible bruits were detected. Her serum potassium concentration was 2.7 mEq/mL, her plasma aldosterone concentration (PAC) was 96.7 ng/dL, and her plasma renin activity (PRA) was 28.1 ng/mL/h. Intrarenal lobar artery flow pattern assessed by Doppler ultrasound showed no abnormality. A renogram demonstrated a normal symmetrical tracing pattern. However, administration of 50 mg captopril induced delayed transit of tracer in both kidneys. Selective angiographic studies showed no stenotic lesions in the proximal to distal renal arteries. Blood sampling from each renal vein showed no laterality of PRA. While the possibility of the Page kidney phenomenon resulting from ESWL could not be excluded completely, the patient was diagnosed as a very rare case of hyperreninemic essential hypertension with positive captopril renography in both kidneys.
Authors:
Takafumi Okura; Jun Irita; Daijiro Enomoto; Seiko Manabe; Mie Kurata; Ken-Ichi Miyoshi; Tomikazu Fukuoka; Jitsuo Higaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  31     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  IM    
Affiliation:
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan. okura@m.ehime-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Captopril / diagnostic use*
Female
Humans
Hypertension, Renovascular / diagnosis,  etiology*
Hypokalemia / etiology
Lithotripsy / adverse effects
Radioisotope Renography*
Renal Artery Obstruction / complications*
Renin / blood*
Chemical
Reg. No./Substance:
62571-86-2/Captopril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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