| A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA(1c). | |
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MedLine Citation:
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PMID: 22484594 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA(1c) level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia. |
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Authors:
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Hisakazu Nishimori; Keiko Harano; Hideho Wada; Satoshi Takano; Shinji Fukuda; Yukihito Takehara; Hiroshi Matsumoto; Isao Kumagai; Mitsune Tanimoto; Sho Takeda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-8 |
Journal Detail:
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Title: International journal of hematology Volume: - ISSN: 1865-3774 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Teraoka Memorial Hospital, Fukuyama, Japan, n-mori@md.okayama-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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