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A case of glyburide-induced leukocytoclastic vasculitis.
MedLine Citation:
PMID:  24050293     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: Medication-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity dependent areas. Development of the vasculitis occurs within weeks after the initial administration of the medication, with clearance upon withdrawal of the medication. Glyburide, a sulfonylurea medication, is used to treat non-insulin dependent diabetes mellitus. We report a rare case of glyburide-associated leukocytoclastic vasculitis. Observation: We report a 71-year-old man with type 2 diabetes mellitus who presented with palpable purpura on the lower extremities. Cutaneous biopsy revealed superficial small vessel vasculitis with IgA perivascular deposits. Further questioning revealed three prior episodes of palpable purpura after restarting the glyburide medication, with clearance upon discontinuation. We diagnosed drug-induced vasculitis related to the glyburide. Conclusions: This case highlights a rarely reported cutaneous adverse reaction to the commonly used diabetic medication, glyburide. Physicians should consider cutaneous vasculitis as a potential side effect of glyburide. Abbreviations: LCV (Leukocytoclastic vasculitis), c-ANCA (centrally accentuated anti-neutrophilic cytoplasmic antibody), p-ANCA (Perinuclear anti-neutrophilic cytoplasmic antibody), anti-TNF-alpha (anti-tumor necrosis factor alpha).
Authors:
Jill K Henley; Joseph A Blackmon; Garth R Fraga; Anand Rajpara; Mehrdad Maz
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Publication Detail:
Type:  Journal Article     Date:  2013-09-14
Journal Detail:
Title:  Dermatology online journal     Volume:  19     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-09-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19619     Citation Subset:  IM    
Affiliation:
University of Kansas Medical Center.
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