| A case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 18839063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 49-year-old man was admitted to our hospital with mild proteinuria. Prior to admission, he had been diagnosed as having Sjögren's syndrome in association with primary biliary cirrhosis. Examination of a renal biopsy under light microscopy revealed diffuse and global mesangial cell proliferation and a spike and/or bubbling formation of the glomerular basement membrane (GBM), resembling membranoproliferative glomerulonephritis. In contrast, immunofluorescent studies showed marked immunoglobulin and complement depositions in the mesangial areas; however, only faint granular IgG and IgA deposition was observed along the GBM. Interestingly, electron microscopy revealed that a microtubular structure, derived from podocytes, was present in the GBM. We present a case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis. |
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Authors:
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Kentaro Koike; Yasunori Utsunomiya; Yoriko Ito; Satori Tokudome; Yoichi Miyazaki; Takahide Suzuki; Hideo Okonogi; Tetsuya Kawamura; Akio Yamada; Tatsuo Hosoya; Kensuke Joh |
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Publication Detail:
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Type: Journal Article Date: 2008-10-07 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 12 ISSN: 1342-1751 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 489-93 Citation Subset: IM |
Affiliation:
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Division of Kidney and Hypertension, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Glomerular Basement Membrane
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pathology*,
ultrastructure Humans Liver Cirrhosis, Biliary / complications, pathology* Male Microspheres Middle Aged Podocytes / pathology*, ultrastructure Sjogren's Syndrome / complications, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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