Document Detail

A case of giant cell reparative granuloma of the petrous bone: demonstration of the proliferative component.
MedLine Citation:
PMID:  9199687     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Giant cell reparative granuloma (GCRG) is an uncommon benign lesion of the bone. It typically arises in the mandible and rarely involves the skull. The cytologic nature and genesis of the involved cells are poorly understood. METHODS AND RESULTS: We report a case of GCRG in the petrous bone of a 3-year-old girl. One year following gross total removal, the granuloma recurred locally and was resected en bloc at the second surgery. Histologically, the lesion was composed of oval or spindle-shaped stroma cells admixed with a number of multinucleated giant cells. Immunohistochemical study demonstrated that 5.6% of the stroma cells, but none of the multinucleated giant cells, were positive for MIB-1 antibody. CONCLUSION: These results suggest that this lesion expands by proliferation of the stromal component, with a growth rate roughly between those of the typical benign and malignant brain tumors. The cytologic nature of the cells comprising this uncommon disease remains to be elucidated.
M Maruno; T Yoshimine; T Kubo; T Hayakawa
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgical neurology     Volume:  48     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
Department of Neurosurgery, Osaka University Medical School, Japan.
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MeSH Terms
Child, Preschool
Granuloma, Giant Cell* / pathology,  radiography,  surgery
Magnetic Resonance Imaging
Petrous Bone* / pathology,  radiography,  surgery
Tomography, X-Ray Computed

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