Document Detail


A case of flutamide-induced acute cholestatic hepatitis--a case report.
MedLine Citation:
PMID:  8826789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Flutamide, an oral nonsteroidal, antiandrogenic, anilid compound which inhibits the uptake and binding of androgens to nuclear receptors in the prostate, is used with or without LH-RH analogues for treatment of patients with metastatic carcinoma of the prostate. Clinically significant hepatotoxicities such as toxic hepatitis, cholestatic hepatitis, hepatic failure, and even death have rarely been reported in the English literature, but no case has been reported in Korea. A 75-year-old man with metastatic carcinoma of the prostate had taken flutamide (750 mg/day) for 7 months and suddenly developed jaundice and general weakness. The findings of blood chemistries were compatible with cholestatic hepatitis, but ultrasonography, viral marker and auto-antibody studies did not reveal any attributable causes. Histologic examination of a sono-guided liver biopsy only disclosed centrilobular cholestasis, nuclear glycogenosis and mild sinusoidal lymphocytic infiltration. Discontinuation of flutamide resulted in an almost full recovery of the patient's liver function in 2 months. We, herein, report a case of flutamide-induced acute choestatic hepatitis with a brief review of the literature.
Authors:
H W Lee; J P Chung; K S Lee; K C Kim; K S Lee; C Y Chon; I S Park; H G Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Yonsei medical journal     Volume:  37     ISSN:  0513-5796     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-06     Completed Date:  1996-11-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Androgen Antagonists / adverse effects*
Cholestasis / chemically induced*
Drug-Induced Liver Injury / etiology*
Flutamide / adverse effects*
Humans
Male
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 13311-84-7/Flutamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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