| A case of fibromatosis of the breast. | |
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MedLine Citation:
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PMID: 12016399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 36-year-old woman presented with a 10 mm diameter mass in the right breast. Since the mass persisted for 3 months after detection and mammary carcinoma was suspected based on ultrasonographic findings, the mass was resected. Histologically, the mass demonstrated proliferative margins and consisted of spindle cells with bland cytologic features and abundant collagen. Immunohistochemically, the spindle cells were positive for vimentin and smooth muscle actin, and were negative for cytokeratins and desmin. Furthermore, the cells showed MIB-1 immunoreactivity with a MIB-1 labeling index of 4.1. Based on these findings, was diagnosed fibromatosis. Breast fibromatosis is rare and is usually misdiagnosed as breast carcinoma preoperatively. To date, only 10 cases of breast fibromatosis have been reported in Japan. Among the reported cases in Japan, our patient presented with the smallest mass, and ultrasonographic findings in this case were the same as those of other cases. Our experience and a review of the literature indicated that differentiation of fibromatosis from carcinoma is very difficult by ultrasonographic examination. In our case, despite involvement of the surgical margins, there was no recurrence. This may be attributed to the small size of the mass and focal exposure. |
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Authors:
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Hirohiko Yamaguchi; Takashi Sakakibara; Mako Hino; Misa Ryu; Kouji Senuma; Katsuya Nakai; Yuichi Tomiki; Kazuhiro Sakamoto; Toshiki Kamano; Masahiko Tsurumaru; Toshiharu Matsumoto |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Breast cancer (Tokyo, Japan) Volume: 9 ISSN: 1340-6868 ISO Abbreviation: Breast Cancer Publication Date: 2002 |
Date Detail:
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Created Date: 2002-05-17 Completed Date: 2002-10-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100888201 Medline TA: Breast Cancer Country: Japan |
Other Details:
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Languages: eng Pagination: 175-8 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis,
pathology*,
surgery Adult Biopsy, Needle Breast Neoplasms / diagnosis, pathology*, surgery Diagnosis, Differential Female Fibroma / diagnosis, pathology*, surgery Follow-Up Studies Humans Immunohistochemistry Japan Mammography / methods Mastectomy, Segmental Ultrasonography, Doppler |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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