Document Detail

A case of extended late-phase in-stent restenosis after implantation of a bare-metal stent: intravascular ultrasound, optical coherence tomography and immunohistochemical findings.
MedLine Citation:
PMID:  21474860     Owner:  NLM     Status:  In-Data-Review    
Although extended late-phase in-stent restenosis has been reported even after implantation of bare-metal stents (BMS), the data resolving the mechanism are sparse. We could obtain intravascular ultrasound, optical coherence tomography (OCT), and immunohistochemical findings by retrieving the material that prolapsed distal to the stent after balloon angioplasty for the in-stent restenosis 12 years after BMS implantation in a 76-year-old man. OCT showed homogeneous high signal in the distal segment and high signal accompanied by attenuation in the proximal segment. Low signals around the stent struts and tubular structure in the deep layer were also detected, suggesting the existence of inflammation and neovascularization, respectively. Fibrous collagenous plaque was adjacent to the lesion where polymorphic smooth muscle cells (immunoreactivity to smooth muscle cell α-actin) proliferates with rich proteoglycan at the background with invasion of macrophages (immunoreactivity to CD 68) as a border. These findings may indicate the multiple healing process after plaque rupture or erosion even in the stented coronary segment.
Shigenori Ito; Takayuki Yoshida; Shugo Suzuki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  23     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E86-91     Citation Subset:  IM    
Division of Cardiology, East Medical Center, Higashi Municipal Hospital City of Nagoya, 1-2-23, Wakamizu-cho, Chikusa-ku, Nagoya-shi, Aichi-ken, 464-8547, Japan.
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